The Rune system in Diablo 4 brings back a fan-favorite mechanic from Diablo 2, allowing players to combine Runes into gear to create powerful and customizable Runewords. These combinations serve as trigger-and-effect enchantments, opening up endless possibilities for gameplay customization. Unlocking this system is an exciting milestone for any adventurer in Diablo 4, and it begins with the Vessel of Hatred DLC.
To gain access to Runes, players must complete the "Fundament of Faith" quest during the Vessel of Hatred campaign. This critical quest not only introduces the Rune system but also rewards you with your first set of diablo 4 runes sale. Keep in mind that the Rune system is exclusive to the Vessel of Hatred DLC and cannot be accessed in the base game.
